:root{--sps-blue:#2979FF;--sps-blue-dim:#1565C0;--sps-blue-glow:rgba(41, 121, 255, 0.25);--sps-blue-subtle:rgba(41, 121, 255, 0.08);--sps-cyan:#00E5FF;--sps-light-blue:#82B1FF;--sps-purple:#7C4DFF;--sps-section-gap:clamp(4rem, 8vw, 7rem);--sps-glass-bg:rgba(8, 12, 28, 0.58);--sps-glass-border:rgba(41, 121, 255, 0.16);--sps-card-shadow:0 4px 24px rgba(0, 0, 0, 0.3), inset 0 1px 0 rgba(255, 255, 255, 0.05);--sps-glow-blue:0 0 20px rgba(41, 121, 255, 0.20), 0 0 40px rgba(41, 121, 255, 0.08);--sps-tier-core:#2979FF;--sps-tier-evidence:#00E5FF;--sps-tier-emerging:#7C4DFF;--sps-focus-ring:0 0 0 3px rgba(41, 121, 255, 0.6);--sps-focus-ring-offset:0 0 0 1px var(--color-bg-primary, #020617), 0 0 0 4px var(--sps-blue)}.mode-light{--sps-glass-bg:rgba(240, 245, 255, 0.82);--sps-glass-border:rgba(21, 101, 192, 0.18);--sps-card-shadow:0 4px 16px rgba(0, 0, 0, 0.08), inset 0 1px 0 rgba(255, 255, 255, 0.6);--sps-glow-blue:0 0 16px rgba(21, 101, 192, 0.12), 0 0 30px rgba(21, 101, 192, 0.06);--sps-blue-glow:rgba(21, 101, 192, 0.18);--sps-blue-subtle:rgba(41, 121, 255, 0.06);--sps-focus-ring-offset:0 0 0 1px var(--color-bg-primary, #F8F8FC), 0 0 0 4px var(--sps-blue-dim)}.sps-page *:focus-visible{outline:none;box-shadow:var(--sps-focus-ring-offset);border-radius:var(--radius-xs)}@media (prefers-reduced-motion:reduce){.sps-page *,.sps-page *::before,.sps-page *::after{animation-duration:0.01ms!important;animation-iteration-count:1!important;transition-duration:0.01ms!important;scroll-behavior:auto!important}}@media (forced-colors:active){.sps-page .hero h1,.sps-page .section-title,.sps-page .subsection-title,.sps-page .variant-name,.sps-page .tier-badge{-webkit-text-fill-color:currentColor;background:none;animation:none;filter:none}.sps-page .hero,.sps-page .content-section,.sps-page .breaking-news,.sps-page .sps-toc .byr-toc-inner,.sps-page .chrome-border,.sps-page .patient-quote,.sps-page .metaphor-box,.sps-page .info-box,.sps-page .warning-box,.sps-page .critical-callout,.sps-page .treatment-tier,.sps-page .resource-card,.sps-page .fact-card,.sps-page .variant-card{background:#fff0;border:1px solid ButtonText}.sps-page .timeline::before{background:ButtonText}.sps-page .timeline-marker{background:ButtonText;border-color:ButtonText}}@keyframes sps-title-gradient{0%{background-position:0% 50%}25%{background-position:50% 50%}50%{background-position:100% 50%}75%{background-position:50% 50%}100%{background-position:0% 50%}}@keyframes sps-section-gradient{0%{background-position:0% 50%}50%{background-position:100% 50%}100%{background-position:0% 50%}}@keyframes sps-border-flow{0%,100%{background-position:0% 0%}50%{background-position:0% 100%}}@keyframes sps-pulse{0%{box-shadow:0 0 0 0 rgb(41 121 255 / .4),0 0 12px var(--sps-blue-glow)}50%{box-shadow:0 0 0 6px #fff0,0 0 20px rgb(0 229 255 / .25)}100%{box-shadow:0 0 0 0 rgb(41 121 255 / .4),0 0 12px var(--sps-blue-glow)}}@keyframes sps-marker-pulse{0%{box-shadow:0 0 0 0 rgb(41 121 255 / .45),0 0 12px var(--sps-blue-glow)}50%{box-shadow:0 0 0 8px #fff0,0 0 20px rgb(41 121 255 / .3)}100%{box-shadow:0 0 0 0 rgb(41 121 255 / .45),0 0 12px var(--sps-blue-glow)}}@keyframes sps-hero-shimmer{0%{left:-120%;opacity:0}10%{opacity:1}100%{left:120%;opacity:0}}.sps-page{width:100%;margin:0 auto;padding:0}.entry-content .sps-page{max-width:var(--two-col-max-width);margin-inline:auto}.sps-page .hero{width:100%;padding:clamp(3rem, 6vw, 5rem) clamp(1.5rem, 4vw, 3rem);text-align:center;position:relative;overflow:hidden;isolation:isolate;background:var(--sps-glass-bg);backdrop-filter:blur(14px);-webkit-backdrop-filter:blur(14px);border:1px solid var(--sps-glass-border);border-radius:var(--radius-xl);box-shadow:var(--sps-card-shadow);animation:byr-e-rise 0.8s cubic-bezier(.16,1,.3,1) both}.sps-page .hero::before{content:'';position:absolute;inset:0;z-index:0;pointer-events:none;background:radial-gradient(ellipse 80% 60% at 50% 110%,rgb(41 121 255 / .14) 0%,transparent 65%),radial-gradient(ellipse 50% 40% at 20% -10%,rgb(0 229 255 / .06) 0%,transparent 60%)}.sps-page .hero::after{content:'';position:absolute;inset:0;z-index:2;pointer-events:none;width:60%;height:100%;top:0;background:linear-gradient(110deg,transparent 0%,rgb(255 255 255 / .03) 40%,rgb(255 255 255 / .07) 50%,rgb(255 255 255 / .03) 60%,transparent 100%);animation:sps-hero-shimmer 1.8s ease-out 1.2s 1 both}.sps-page .hero>*,.sps-page .hero-content>*{position:relative;z-index:1}.sps-page .hero-content{position:relative;z-index:1}.sps-page .hero h1{font-size:clamp(2.25rem, 5vw, 3.5rem);font-weight:900;line-height:var(--leading-tight,1.15);margin:0 0 .75rem;letter-spacing:-.02em;background:linear-gradient(125deg,#2979FF 0%,#448AFF 15%,#82B1FF 28%,#00E5FF 40%,#FFFFFF 52%,#00E5FF 64%,#82B1FF 76%,#2979FF 88%,#1565C0 100%);background-size:300% 300%;-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:#fff0;color:#fff0;animation:sps-title-gradient 8s ease-in-out infinite;filter:drop-shadow(0 2px 8px rgb(41 121 255 / .35))}.sps-page .hero-subtitle{font-size:var(--text-xl,1.375rem);color:var(--color-text-secondary,#C7C7D8);margin:0 0 1rem;line-height:var(--leading-snug,1.3);text-shadow:0 0 20px rgb(41 121 255 / .12)}.sps-page .hero-tagline{font-size:var(--text-lg,1.125rem);font-style:italic;color:var(--color-text-primary,#F5F5F8);margin:1rem auto 0;max-width:60ch;line-height:var(--leading-relaxed,1.7);text-shadow:0 0 16px rgb(41 121 255 / .08)}.sps-page .container{padding:var(--space-xl,3rem) 0 0;margin:0 auto}.sps-page .sps-toc{scrollbar-width:thin;scrollbar-color:rgb(41 121 255 / .25) #fff0}.sps-page .sps-toc .byr-toc-inner{background:var(--sps-glass-bg);backdrop-filter:blur(12px);-webkit-backdrop-filter:blur(12px);border:1px solid var(--sps-glass-border);border-left:3px solid var(--sps-blue);box-shadow:var(--sps-card-shadow)}.sps-page .sps-toc .byr-toc-label{color:var(--sps-blue)}.sps-page .sps-toc a{color:var(--color-text-muted,#8A8A9A);border-left:2px solid #fff0;transition:color 0.25s ease,border-color 0.25s ease,background 0.25s ease,box-shadow 0.25s ease}.sps-page .sps-toc a:hover{color:var(--color-text-primary,#F5F5F8);background:var(--sps-blue-subtle)}.sps-page .sps-toc a[aria-current="true"]{color:var(--sps-blue);font-weight:600;border-left-color:var(--sps-blue);background:var(--sps-blue-subtle);box-shadow:-2px 0 12px rgb(41 121 255 / .15)}.sps-page .breaking-news{padding:var(--space-lg,2rem);border-radius:var(--radius-lg);position:relative;overflow:hidden;margin-bottom:var(--sps-section-gap);background:var(--sps-glass-bg);backdrop-filter:blur(12px);-webkit-backdrop-filter:blur(12px);border:2px solid rgb(41 121 255 / .3);box-shadow:var(--sps-card-shadow);animation:sps-pulse 3s ease-in-out infinite}.sps-page .breaking-news::before{content:'';position:absolute;inset:0;z-index:0;pointer-events:none;background:radial-gradient(ellipse 70% 50% at 50% 100%,rgb(0 229 255 / .06) 0%,transparent 70%)}.sps-page .breaking-news>*{position:relative;z-index:1}.sps-page .breaking-news-header{display:flex;align-items:center;gap:10px;margin-bottom:var(--space-md,1.5rem);padding-bottom:var(--space-sm,1rem);border-bottom:1px solid rgb(41 121 255 / .15);font-size:var(--text-sm,.875rem);font-weight:800;text-transform:uppercase;letter-spacing:.06em;color:var(--sps-cyan)}.sps-page .breaking-news-icon{font-size:var(--text-xl,1.375rem);line-height:1}.sps-page .breaking-news-content h3{font-size:var(--text-2xl,1.75rem);font-weight:900;color:var(--color-heading,#FFFFFF);margin:0 0 var(--space-sm,1rem);line-height:var(--leading-tight,1.15)}.sps-page .breaking-news-content p{font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8);line-height:var(--leading-relaxed,1.7);margin:0 0 var(--space-sm,1rem)}.sps-page .breaking-news-content p:last-child{margin-bottom:0}.sps-page .breaking-news-stats{display:grid;grid-template-columns:repeat(auto-fit,minmax(180px,1fr));gap:var(--space-md,1.5rem);margin:var(--space-lg,2rem) 0}.sps-page .stat-item{display:flex;flex-direction:column;gap:4px;padding:var(--space-sm,1rem);border-radius:var(--radius-md);background:rgb(41 121 255 / .06);border:1px solid rgb(41 121 255 / .12);text-align:center;transition:background 0.3s ease,border-color 0.3s ease}.sps-page .stat-item:hover{background:rgb(41 121 255 / .1);border-color:rgb(41 121 255 / .25)}.sps-page .stat-value{font-size:clamp(2rem, 4vw, 2.75rem);font-weight:900;color:var(--sps-blue);line-height:1;letter-spacing:-.02em;filter:drop-shadow(0 0 8px rgb(41 121 255 / .25))}.sps-page .stat-label{font-size:var(--text-sm,.875rem);color:var(--color-text-secondary,#C7C7D8);line-height:var(--leading-snug,1.3)}.sps-page .content-section{margin-bottom:var(--space-lg,2rem);animation:byr-e-rise 0.8s cubic-bezier(.16,1,.3,1) both}.sps-page .section-title{font-size:var(--text-2xl,1.75rem);font-weight:900;margin:0 0 var(--space-md,1.5rem);line-height:var(--leading-tight,1.15);letter-spacing:-.01em;background:linear-gradient(125deg,#2979FF 0%,#448AFF 20%,#00E5FF 40%,#FFFFFF 55%,#00E5FF 70%,#2979FF 90%,#1565C0 100%);background-size:300% 300%;-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:#fff0;color:#fff0;animation:sps-section-gradient 10s ease-in-out infinite}.sps-page .subsection-title{font-size:var(--text-xl,1.375rem);font-weight:800;color:var(--color-heading,#FFFFFF);margin:var(--space-lg,2rem) 0 var(--space-sm,1rem);padding-left:var(--space-sm,1rem);border-left:3px solid rgb(41 121 255 / .4);line-height:var(--leading-snug,1.3)}.sps-page .content-section p{font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8);line-height:var(--leading-relaxed,1.7);margin:0 0 var(--space-sm,1rem);max-width:70ch}.sps-page .content-section p:last-child{margin-bottom:0}.sps-page .content-section strong{color:var(--sps-blue);font-weight:700}.sps-page .quick-facts{display:grid;grid-template-columns:repeat(auto-fit,minmax(240px,1fr));gap:var(--space-md,1.5rem);margin-top:var(--space-md,1.5rem)}.sps-page .fact-card{padding:var(--space-md,1.5rem);border-radius:var(--radius-md);position:relative;overflow:hidden;background:var(--sps-glass-bg);backdrop-filter:blur(8px);-webkit-backdrop-filter:blur(8px);border:1px solid var(--sps-glass-border);box-shadow:var(--sps-card-shadow);transition:border-color 0.3s ease,transform 0.3s cubic-bezier(.16,1,.3,1),box-shadow 0.3s ease}.sps-page .fact-card::before{content:'';position:absolute;top:0;left:0;right:0;height:3px;background:linear-gradient(90deg,var(--sps-blue),var(--sps-cyan));border-radius:var(--radius-md) var(--radius-md) 0 0}.sps-page .fact-card:hover{border-color:rgb(41 121 255 / .35);transform:translateY(-3px);box-shadow:var(--sps-glow-blue),var(--sps-card-shadow)}.sps-page .fact-label{font-size:var(--text-sm,.875rem);font-weight:700;text-transform:uppercase;letter-spacing:.04em;color:var(--sps-blue);margin:0 0 6px}.sps-page .fact-value{font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8);line-height:var(--leading-normal,1.5)}.sps-page .fact-card:nth-child(1){animation:byr-e-rise 0.65s cubic-bezier(.16,1,.3,1) 0.10s both}.sps-page .fact-card:nth-child(2){animation:byr-e-rise 0.65s cubic-bezier(.16,1,.3,1) 0.20s both}.sps-page .fact-card:nth-child(3){animation:byr-e-rise 0.65s cubic-bezier(.16,1,.3,1) 0.30s both}.sps-page .fact-card:nth-child(4){animation:byr-e-rise 0.65s cubic-bezier(.16,1,.3,1) 0.40s both}.sps-page .chrome-border{position:relative;padding:3px;border-radius:calc(var(--radius-lg) + 3px);overflow:hidden;background:linear-gradient(180deg,var(--sps-blue) 0%,var(--sps-cyan) 25%,var(--sps-light-blue) 50%,var(--sps-cyan) 75%,var(--sps-blue) 100%);background-size:100% 300%;animation:sps-border-flow 4s ease infinite}.sps-page .chrome-border-inner{padding:var(--space-lg,2rem) var(--space-lg,2rem);border-radius:var(--radius-lg);background:var(--sps-glass-bg);backdrop-filter:blur(12px);-webkit-backdrop-filter:blur(12px)}.sps-page .chrome-border-inner p{font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8);line-height:var(--leading-relaxed,1.7);margin:0 0 var(--space-sm,1rem);max-width:70ch}.sps-page .chrome-border-inner p:last-child{margin-bottom:0}.sps-page .chrome-border-inner strong{color:var(--sps-blue);font-weight:700}.sps-page .chrome-border-inner .content-list{margin-top:var(--space-sm,1rem)}.sps-page .patient-quote{position:relative;margin:var(--space-lg,2rem) 0;padding:var(--space-md,1.5rem) var(--space-md,1.5rem) var(--space-md,1.5rem) var(--space-lg,2rem);border-radius:0 var(--radius-lg) var(--radius-lg) 0;background:var(--sps-glass-bg);backdrop-filter:blur(8px);-webkit-backdrop-filter:blur(8px);border:1px solid var(--sps-glass-border);border-left:none;box-shadow:var(--sps-card-shadow);transition:border-color 0.3s ease,box-shadow 0.3s ease;animation:byr-e-fade 0.8s ease 0.3s both}.sps-page .patient-quote::before{content:'';position:absolute;left:0;top:10%;bottom:10%;width:4px;border-radius:2px;background:linear-gradient(180deg,transparent 0%,var(--sps-blue) 25%,var(--sps-cyan) 50%,var(--sps-blue) 75%,transparent 100%);background-size:100% 200%;animation:sps-border-flow 3s ease infinite}.sps-page .patient-quote::after{content:"\201C";position:absolute;top:-12px;left:14px;font-size:6rem;font-weight:900;color:var(--sps-blue);opacity:.35;line-height:1;pointer-events:none}.sps-page .patient-quote:hover{border-color:rgb(41 121 255 / .3);box-shadow:var(--sps-glow-blue),var(--sps-card-shadow)}.sps-page .quote-text{font-size:var(--text-lg,1.125rem);font-style:italic;line-height:var(--leading-relaxed,1.7);color:var(--color-text-primary,#F5F5F8);margin:0 0 var(--space-xs,.75rem)}.sps-page .quote-author{font-size:var(--text-sm,.875rem);color:var(--sps-light-blue);font-weight:600;font-style:normal;margin:0}.sps-page .metaphor-box{display:flex;gap:var(--space-md,1.5rem);align-items:flex-start;padding:var(--space-md,1.5rem);margin:var(--space-md,1.5rem) 0;border-radius:var(--radius-lg);background:linear-gradient(135deg,rgb(41 121 255 / .06) 0%,var(--sps-glass-bg) 100%);backdrop-filter:blur(10px);-webkit-backdrop-filter:blur(10px);border:1px solid rgb(41 121 255 / .2);box-shadow:var(--sps-card-shadow);transition:border-color 0.3s ease,box-shadow 0.3s ease}.sps-page .metaphor-box:hover{border-color:rgb(41 121 255 / .35);box-shadow:var(--sps-glow-blue),var(--sps-card-shadow)}.sps-page .metaphor-icon{width:56px;height:56px;border-radius:50%;background:rgb(41 121 255 / .1);border:1px solid rgb(41 121 255 / .22);display:flex;align-items:center;justify-content:center;font-size:var(--text-2xl,1.75rem);flex-shrink:0;line-height:1;transition:background 0.3s ease,box-shadow 0.3s ease}.sps-page .metaphor-box:hover .metaphor-icon{background:rgb(41 121 255 / .18);box-shadow:0 0 16px rgb(41 121 255 / .2)}.sps-page .metaphor-title{font-size:var(--text-lg,1.125rem);font-weight:800;color:var(--sps-blue);margin:0 0 var(--space-2xs,.5rem);line-height:var(--leading-tight,1.15)}.sps-page .metaphor-text{font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8);line-height:var(--leading-relaxed,1.7);margin:0}.sps-page .content-list{list-style:none;margin:var(--space-sm,1rem) 0;padding:0 0 0 var(--space-md,1.5rem);border-left:2px solid rgb(41 121 255 / .15)}.sps-page .content-list li{position:relative;padding:var(--space-2xs,.5rem) 0 var(--space-2xs,.5rem) var(--space-sm,1rem);font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8);line-height:var(--leading-relaxed,1.7)}.sps-page .content-list li::before{content:'';position:absolute;left:-7px;top:calc(var(--space-2xs, 0.5rem) + 0.6em);width:8px;height:8px;border-radius:50%;background:var(--sps-blue);box-shadow:0 0 6px rgb(41 121 255 / .3);transform:translateY(-50%)}.sps-page .content-list li strong{color:var(--sps-blue);font-weight:700}.sps-page .info-box{margin:var(--space-md,1.5rem) 0;padding:var(--space-md,1.5rem);border-radius:var(--radius-md);position:relative;background:var(--sps-glass-bg);backdrop-filter:blur(8px);-webkit-backdrop-filter:blur(8px);border:1px solid var(--sps-glass-border);box-shadow:var(--sps-card-shadow);border-left:4px solid var(--sps-blue)}.sps-page .info-box-title{font-size:var(--text-md,1rem);font-weight:800;color:var(--sps-blue);margin:0 0 var(--space-xs,.75rem);line-height:var(--leading-tight,1.15)}.sps-page .info-box p{font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8);line-height:var(--leading-relaxed,1.7);margin:0}.sps-page .info-box strong{color:var(--sps-blue);font-weight:700}.sps-page .warning-box{margin:var(--space-md,1.5rem) 0;padding:var(--space-md,1.5rem);border-radius:var(--radius-md);background:var(--sps-glass-bg);backdrop-filter:blur(8px);-webkit-backdrop-filter:blur(8px);border:1px solid rgb(251 191 36 / .16);box-shadow:var(--sps-card-shadow);border-left:4px solid #FBB924}.sps-page .warning-box .info-box-title{color:#FBB924}.sps-page .warning-box p{font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8);line-height:var(--leading-relaxed,1.7);margin:0}.sps-page .warning-box strong{color:#FBB924;font-weight:700}.sps-page .timeline{position:relative;padding-left:36px;margin:var(--space-md,1.5rem) 0}.sps-page .timeline::before{content:"";position:absolute;left:7px;top:0;bottom:0;width:3px;background:linear-gradient(180deg,var(--sps-blue) 0%,var(--sps-cyan) 20%,var(--sps-blue) 50%,rgb(41 121 255 / .35) 80%,transparent 100%)}.sps-page .timeline-item{position:relative;padding-bottom:var(--space-lg,2rem);display:grid;grid-template-columns:auto 1fr;grid-template-rows:auto auto;gap:0 var(--space-sm,1rem);align-items:baseline;transition:background 0.3s ease}.sps-page .timeline-item:last-child{padding-bottom:0}.sps-page .timeline-marker{position:absolute;left:-36px;top:4px;width:16px;height:16px;border-radius:50%;background:var(--color-bg-primary,#020617);border:3px solid var(--sps-blue);z-index:var(--z-content,1);transition:background 0.3s ease,box-shadow 0.3s ease}.sps-page .timeline-item:hover .timeline-marker{background:var(--sps-blue);animation:sps-marker-pulse 2s ease-in-out infinite}.sps-page .timeline-year{font-size:var(--text-sm,.875rem);font-weight:800;color:var(--sps-blue);letter-spacing:.04em;margin:0 0 4px;grid-column:1 / -1}.sps-page .timeline-content{font-size:var(--text-md,1rem);color:var(--color-text-secondary,#C7C7D8);line-height:var(--leading-normal,1.5);margin:0;grid-column:1 / -1}.sps-page .timeline-content strong{color:var(--color-heading,#FFFFFF);font-weight:700}.sps-page .timeline-item:hover{background:rgb(41 121 255 / .035);border-radius:var(--radius-md);padding-left:var(--space-sm,1rem);margin-left:calc(-1 * var(--space-sm, 1rem))}.sps-page .variant-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(260px,1fr));gap:var(--space-md,1.5rem);margin-top:var(--space-md,1.5rem)}.sps-page .variant-card{padding:var(--space-md,1.5rem);padding-top:calc(var(--space-md, 1.5rem) + 4px);border-radius:var(--radius-lg);position:relative;overflow:hidden;background:var(--sps-glass-bg);backdrop-filter:blur(10px);-webkit-backdrop-filter:blur(10px);border:1px solid var(--sps-glass-border);box-shadow:var(--sps-card-shadow);transition:border-color 0.3s ease,transform 0.3s cubic-bezier(.16,1,.3,1),box-shadow 0.3s ease}.sps-page .variant-card::before{content:'';position:absolute;top:0;left:0;right:0;height:3px;border-radius:var(--radius-lg) var(--radius-lg) 0 0}.sps-page .variant-card:nth-child(6n+1)::before{background:linear-gradient(90deg,#2979FF,#448AFF);box-shadow:0 0 12px rgb(41 121 255 / .4)}.sps-page .variant-card:nth-child(6n+2)::before{background:linear-gradient(90deg,#00E5FF,#18FFFF);box-shadow:0 0 12px rgb(0 229 255 / .4)}.sps-page .variant-card:nth-child(6n+3)::before{background:linear-gradient(90deg,#7C4DFF,#B388FF);box-shadow:0 0 12px rgb(124 77 255 / .4)}.sps-page .variant-card:nth-child(6n+4)::before{background:linear-gradient(90deg,#82B1FF,#2979FF);box-shadow:0 0 12px rgb(130 177 255 / .4)}.sps-page .variant-card:nth-child(6n+5)::before{background:linear-gradient(90deg,#00B8D4,#00E5FF);box-shadow:0 0 12px rgb(0 184 212 / .4)}.sps-page .variant-card:nth-child(6n+6)::before{background:linear-gradient(90deg,#651FFF,#7C4DFF);box-shadow:0 0 12px rgb(101 31 255 / .4)}.sps-page .variant-card:hover{border-color:rgb(41 121 255 / .38);transform:translateY(-4px);box-shadow:var(--sps-glow-blue),var(--sps-card-shadow)}.sps-page .variant-name{font-size:var(--text-lg,1.125rem);font-weight:800;color:var(--color-heading,#FFFFFF);margin:0 0 var(--space-2xs,.5rem);line-height:var(--leading-tight,1.15)}.sps-page .variant-description{font-size:var(--text-md,1rem);color:var(--color-text-secondary,#C7C7D8);line-height:var(--leading-normal,1.5);margin:0}.sps-page .critical-callout{padding:var(--space-lg,2rem);border-radius:var(--radius-lg);margin-bottom:var(--space-lg,2rem);position:relative;overflow:hidden;background:var(--sps-glass-bg);backdrop-filter:blur(12px);-webkit-backdrop-filter:blur(12px);border:2px solid rgb(239 68 68 / .35);box-shadow:var(--sps-card-shadow);animation:sps-critical-pulse 2.5s ease-in-out infinite}@keyframes sps-critical-pulse{0%{border-color:rgb(239 68 68 / .35);box-shadow:var(--sps-card-shadow),0 0 0 0 rgb(239 68 68 / .2)}50%{border-color:rgb(251 146 60 / .5);box-shadow:var(--sps-card-shadow),0 0 20px rgb(239 68 68 / .15)}100%{border-color:rgb(239 68 68 / .35);box-shadow:var(--sps-card-shadow),0 0 0 0 rgb(239 68 68 / .2)}}.sps-page .critical-callout::before{content:'';position:absolute;inset:0;z-index:0;pointer-events:none;background:radial-gradient(ellipse 60% 40% at 50% 0%,rgb(239 68 68 / .06) 0%,transparent 65%)}.sps-page .critical-callout>*{position:relative;z-index:1}.sps-page .critical-callout h3{font-size:var(--text-xl,1.375rem);font-weight:900;color:#EF4444;margin:0 0 var(--space-md,1.5rem);line-height:var(--leading-tight,1.15)}.sps-page .critical-callout-content p{font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8);line-height:var(--leading-relaxed,1.7);margin:0 0 var(--space-sm,1rem)}.sps-page .critical-callout-content p:last-child{margin-bottom:0}.sps-page .critical-callout-content strong{color:#EF4444;font-weight:700}.sps-page .critical-callout-content .content-list{border-left-color:rgb(239 68 68 / .2)}.sps-page .critical-callout-content .content-list li::before{background:#EF4444;box-shadow:0 0 6px rgb(239 68 68 / .3)}.sps-page .treatment-tier{margin:var(--space-md,1.5rem) 0;padding:var(--space-md,1.5rem);border-radius:var(--radius-lg);position:relative;background:var(--sps-glass-bg);backdrop-filter:blur(10px);-webkit-backdrop-filter:blur(10px);border:1px solid var(--sps-glass-border);box-shadow:var(--sps-card-shadow);border-left:4px solid var(--sps-blue);transition:border-color 0.3s ease,box-shadow 0.3s ease}.sps-page .treatment-tier:hover{box-shadow:var(--sps-glow-blue),var(--sps-card-shadow)}.sps-page .tier-header{display:flex;align-items:center;gap:var(--space-sm,1rem);margin-bottom:var(--space-sm,1rem)}.sps-page .tier-badge{display:inline-flex;align-items:center;padding:4px 14px;border-radius:var(--radius-pill);font-size:var(--text-sm,.875rem);font-weight:700;text-transform:uppercase;letter-spacing:.04em;line-height:1.4;white-space:nowrap}.sps-page .tier-title{font-size:var(--text-xl,1.375rem);font-weight:800;color:var(--color-heading,#FFFFFF);margin:0;line-height:var(--leading-snug,1.3)}.sps-page .treatment-tier p{font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8);line-height:var(--leading-relaxed,1.7);margin:0 0 var(--space-sm,1rem)}.sps-page .treatment-tier:nth-of-type(1){border-left-color:var(--sps-tier-core)}.sps-page .treatment-tier:nth-of-type(1) .tier-badge{background:rgb(41 121 255 / .12);color:var(--sps-blue);border:1px solid rgb(41 121 255 / .28)}.sps-page .treatment-tier:nth-of-type(2){border-left-color:var(--sps-tier-evidence)}.sps-page .treatment-tier:nth-of-type(2) .tier-badge{background:rgb(0 229 255 / .1);color:var(--sps-cyan);border:1px solid rgb(0 229 255 / .28)}.sps-page .treatment-tier:nth-of-type(2):hover{box-shadow:0 0 20px rgb(0 229 255 / .12),var(--sps-card-shadow)}.sps-page .treatment-tier:nth-of-type(3){border-left-color:var(--sps-tier-emerging)}.sps-page .treatment-tier:nth-of-type(3) .tier-badge{background:rgb(124 77 255 / .1);color:var(--sps-purple);border:1px solid rgb(124 77 255 / .28)}.sps-page .treatment-tier:nth-of-type(3):hover{box-shadow:0 0 20px rgb(124 77 255 / .12),var(--sps-card-shadow)}.sps-page .resource-card{padding:var(--space-md,1.5rem);padding-top:calc(var(--space-md, 1.5rem) + 4px);border-radius:var(--radius-lg);margin:var(--space-md,1.5rem) 0;position:relative;overflow:hidden;background:var(--sps-glass-bg);backdrop-filter:blur(10px);-webkit-backdrop-filter:blur(10px);border:1px solid var(--sps-glass-border);box-shadow:var(--sps-card-shadow);transition:border-color 0.3s ease,transform 0.3s cubic-bezier(.16,1,.3,1),box-shadow 0.3s ease}.sps-page .resource-card::before{content:'';position:absolute;top:0;left:0;right:0;height:3px;background:linear-gradient(90deg,var(--sps-blue),var(--sps-cyan),var(--sps-light-blue));border-radius:var(--radius-lg) var(--radius-lg) 0 0}.sps-page .resource-card:hover{border-color:rgb(41 121 255 / .38);transform:translateY(-3px);box-shadow:var(--sps-glow-blue),var(--sps-card-shadow)}.sps-page .resource-name{font-size:var(--text-lg,1.125rem);font-weight:800;color:var(--color-heading,#FFFFFF);margin:0 0 var(--space-xs,.75rem);line-height:var(--leading-tight,1.15)}.sps-page .resource-description{font-size:var(--text-md,1rem);color:var(--color-text-secondary,#C7C7D8);line-height:var(--leading-normal,1.5);margin:0 0 var(--space-xs,.75rem)}.sps-page .resource-description:last-child{margin-bottom:0}.sps-page .resource-features{list-style:none;margin:var(--space-xs,.75rem) 0 0;padding:0}.sps-page .resource-features li{position:relative;padding:4px 0 4px var(--space-md,1.5rem);font-size:var(--text-sm,.875rem);color:var(--color-text-primary,#F5F5F8);line-height:var(--leading-normal,1.5)}.sps-page .resource-features li::before{content:'';position:absolute;left:4px;top:calc(4px + 0.55em);width:6px;height:6px;border-radius:50%;background:var(--sps-light-blue);box-shadow:0 0 4px rgb(130 177 255 / .3)}.sps-page .mt-lg{margin-top:var(--space-lg,2rem)}.sps-page .mb-xl{margin-bottom:var(--space-xl,3rem)}.sps-page .hero{animation:byr-e-rise 0.8s cubic-bezier(.16,1,.3,1) both}.sps-page .breaking-news{animation:byr-e-rise 0.7s cubic-bezier(.16,1,.3,1) 0.2s both,sps-pulse 3s ease-in-out 1s infinite}.sps-page .content-section:nth-child(1){animation:byr-e-fade 0.6s ease 0.1s both}.sps-page .content-section:nth-child(2){animation:byr-e-fade 0.6s ease 0.15s both}.sps-page .content-section:nth-child(3){animation:byr-e-fade 0.6s ease 0.20s both}.sps-page .content-section:nth-child(n+4){animation:byr-e-fade 0.6s ease 0.25s both}.sps-page .variant-card:nth-child(1){animation:byr-e-rise 0.6s cubic-bezier(.16,1,.3,1) 0.10s both}.sps-page .variant-card:nth-child(2){animation:byr-e-rise 0.6s cubic-bezier(.16,1,.3,1) 0.20s both}.sps-page .variant-card:nth-child(3){animation:byr-e-rise 0.6s cubic-bezier(.16,1,.3,1) 0.30s both}.sps-page .variant-card:nth-child(4){animation:byr-e-rise 0.6s cubic-bezier(.16,1,.3,1) 0.40s both}.sps-page .variant-card:nth-child(5){animation:byr-e-rise 0.6s cubic-bezier(.16,1,.3,1) 0.50s both}.sps-page .variant-card:nth-child(6){animation:byr-e-rise 0.6s cubic-bezier(.16,1,.3,1) 0.60s both}.sps-page .resource-card:nth-child(1){animation:byr-e-rise 0.6s cubic-bezier(.16,1,.3,1) 0.08s both}.sps-page .resource-card:nth-child(2){animation:byr-e-rise 0.6s cubic-bezier(.16,1,.3,1) 0.18s both}.sps-page .resource-card:nth-child(3){animation:byr-e-rise 0.6s cubic-bezier(.16,1,.3,1) 0.28s both}.sps-page .resource-card:nth-child(4){animation:byr-e-rise 0.6s cubic-bezier(.16,1,.3,1) 0.38s both}@media (max-width:768px){.sps-page .hero{padding:clamp(2rem, 4vw, 3rem) clamp(1.25rem, 3vw, 2rem)}.sps-page .breaking-news-stats{grid-template-columns:repeat(2,1fr)}.sps-page .quick-facts{grid-template-columns:1fr}.sps-page .variant-grid{grid-template-columns:1fr}.sps-page .content-section{padding:var(--space-md,1.5rem)}.sps-page .chrome-border-inner{padding:var(--space-md,1.5rem)}.sps-page .metaphor-box{flex-direction:column;align-items:center;text-align:center}.sps-page .fact-card:nth-child(n){animation-delay:0.05s}.sps-page .variant-card:nth-child(n){animation-delay:0.05s}.sps-page .resource-card:nth-child(n){animation-delay:0.05s}}@media (max-width:480px){.sps-page .hero h1{font-size:clamp(1.75rem, 8vw, 2.5rem)}.sps-page .breaking-news{padding:var(--space-md,1.5rem)}.sps-page .breaking-news-stats{grid-template-columns:1fr}.sps-page .stat-value{font-size:clamp(1.5rem, 8vw, 2rem)}.sps-page .patient-quote::after{font-size:4rem}.sps-page .metaphor-icon{width:48px;height:48px;font-size:var(--text-xl)}.sps-page .timeline{padding-left:28px}.sps-page .timeline-marker{left:-28px;width:14px;height:14px}}.mode-light .sps-page .hero,.mode-light .sps-page .content-section,.mode-light .sps-page .breaking-news,.mode-light .sps-page .sps-toc .byr-toc-inner,.mode-light .sps-page .patient-quote,.mode-light .sps-page .metaphor-box,.mode-light .sps-page .info-box,.mode-light .sps-page .warning-box,.mode-light .sps-page .critical-callout,.mode-light .sps-page .treatment-tier,.mode-light .sps-page .resource-card,.mode-light .sps-page .fact-card,.mode-light .sps-page .variant-card,.mode-light .sps-page .chrome-border-inner{background:rgb(240 245 255 / .82)!important;border-color:rgb(21 101 192 / .18)!important}.mode-light .sps-page .stat-item{background:rgb(41 121 255 / .04);border-color:rgb(21 101 192 / .12)}.mode-light .sps-page .content-section p,.mode-light .sps-page .chrome-border-inner p,.mode-light .sps-page .breaking-news-content p,.mode-light .sps-page .quote-text,.mode-light .sps-page .metaphor-text,.mode-light .sps-page .info-box p,.mode-light .sps-page .warning-box p,.mode-light .sps-page .content-list li,.mode-light .sps-page .fact-value,.mode-light .sps-page .variant-description,.mode-light .sps-page .timeline-content,.mode-light .sps-page .resource-features li,.mode-light .sps-page .treatment-tier p,.mode-light .sps-page .critical-callout-content p{color:var(--color-text-primary-light,#0B1530)}.mode-light .sps-page .hero-subtitle,.mode-light .sps-page .stat-label,.mode-light .sps-page .resource-description,.mode-light .sps-page .quote-author{color:var(--color-text-secondary-light,#3B425C)}.mode-light .sps-page .sps-toc a{color:var(--color-text-muted-light,#6B7280)}.mode-light .sps-page .sps-toc a[aria-current="true"]{color:var(--sps-blue-dim)}.mode-light .sps-page .hero h1{background:linear-gradient(125deg,#1565C0 0%,#1976D2 25%,#0D47A1 50%,#1565C0 75%,#1976D2 100%);background-size:300% 300%;-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:#fff0;animation:sps-title-gradient 8s ease-in-out infinite;filter:none}.mode-light .sps-page .section-title{background:linear-gradient(125deg,#1565C0 0%,#1976D2 25%,#0D47A1 45%,#0097A7 60%,#1565C0 80%,#1976D2 100%);background-size:300% 300%;-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:#fff0;animation:sps-section-gradient 10s ease-in-out infinite}.mode-light .sps-page .hero-tagline{color:var(--color-text-primary-light,#0B1530);text-shadow:none}.mode-light .sps-page .subsection-title,.mode-light .sps-page .breaking-news-content h3,.mode-light .sps-page .variant-name,.mode-light .sps-page .resource-name,.mode-light .sps-page .tier-title,.mode-light .sps-page .timeline-content strong{color:var(--color-heading-light,#111827)}.mode-light .sps-page .content-section strong,.mode-light .sps-page .chrome-border-inner strong,.mode-light .sps-page .info-box strong{color:var(--sps-blue-dim)}.mode-light .sps-page .warning-box{background:rgb(255 251 235 / .82)!important;border-color:rgb(180 130 0 / .18)!important}.mode-light .sps-page .critical-callout{background:rgb(255 245 245 / .82)!important;border-color:rgb(239 68 68 / .25)!important}.mode-light .sps-page .chrome-border{background:linear-gradient(180deg,#1565C0 0%,#0097A7 25%,#42A5F5 50%,#0097A7 75%,#1565C0 100%);background-size:100% 300%;animation:sps-border-flow 4s ease infinite}.mode-light .sps-page .timeline::before{background:linear-gradient(180deg,var(--sps-blue-dim) 0%,#0097A7 20%,var(--sps-blue-dim) 50%,rgb(21 101 192 / .35) 80%,transparent 100%)}.mode-light .sps-page .timeline-marker{background:var(--color-bg-primary-light,#F8F8FC);border-color:var(--sps-blue-dim)}.mode-light .sps-page .content-list{border-left-color:rgb(21 101 192 / .18)}.mode-light .sps-page .content-list li::before{background:var(--sps-blue-dim);box-shadow:0 0 4px rgb(21 101 192 / .2)}.mode-light .sps-page .patient-quote::after{color:var(--sps-blue-dim);opacity:.25}.mode-light .sps-page .quote-author{color:var(--sps-blue-dim)}.mode-light .sps-page .breaking-news-header{color:#0097A7;border-bottom-color:rgb(21 101 192 / .15)}.mode-light .sps-page .sps-toc .byr-toc-label{color:var(--sps-blue-dim);border-bottom-color:rgb(21 101 192 / .15)}.mode-light .sps-page .stat-value{color:var(--sps-blue-dim);filter:none}.mode-light .sps-page .fact-label{color:var(--sps-blue-dim)}.mode-light .sps-page .timeline-year{color:var(--sps-blue-dim)}.mode-light .sps-page .info-box-title{color:var(--sps-blue-dim)}.mode-light .sps-page .metaphor-title{color:var(--sps-blue-dim)}.mode-light .sps-page .treatment-tier:nth-of-type(1) .tier-badge{background:rgb(41 121 255 / .08);color:var(--sps-blue-dim);border-color:rgb(21 101 192 / .25)}.mode-light .sps-page .treatment-tier:nth-of-type(2) .tier-badge{background:rgb(0 229 255 / .06);color:#0097A7;border-color:rgb(0 151 167 / .25)}.mode-light .sps-page .treatment-tier:nth-of-type(3) .tier-badge{background:rgb(124 77 255 / .06);color:#6200EA;border-color:rgb(98 0 234 / .25)}.mode-light .sps-page .resource-features li::before{background:var(--sps-blue-dim);box-shadow:0 0 4px rgb(21 101 192 / .2)}.mode-light .sps-page .resource-features li{color:var(--color-text-primary-light,#0B1530)}@media print{.sps-page .sps-toc{display:none}.sps-page .hero,.sps-page .content-section,.sps-page .breaking-news,.sps-page .patient-quote,.sps-page .info-box,.sps-page .warning-box,.sps-page .critical-callout,.sps-page .treatment-tier,.sps-page .resource-card,.sps-page .fact-card,.sps-page .variant-card,.sps-page .chrome-border,.sps-page .chrome-border-inner,.sps-page .metaphor-box{background:#FFFFFF!important;backdrop-filter:none!important;-webkit-backdrop-filter:none!important;box-shadow:none!important;border:1px solid #CCC!important;animation:none!important;break-inside:avoid}.sps-page .hero h1,.sps-page .section-title{-webkit-text-fill-color:#000!important;background:none!important;animation:none!important;filter:none!important;color:#000!important}.sps-page .hero::before,.sps-page .hero::after,.sps-page .breaking-news::before,.sps-page .critical-callout::before{display:none!important}}.sps-story-section{padding-top:var(--sps-section-gap,5rem)}.sps-story-cta{text-align:center;padding:clamp(1.75rem, 4vw, 3rem);background:linear-gradient(145deg,rgb(41 121 255 / .08),transparent);border:1px solid var(--sps-glass-border);border-radius:20px;-webkit-backdrop-filter:blur(10px);backdrop-filter:blur(10px);margin-bottom:3rem}.sps-story-cta h2{font-size:clamp(1.5rem, 3vw, 2rem);color:var(--color-heading);margin:0 0 .6rem;position:relative;display:inline-block}.sps-story-cta h2::after{content:'';display:block;width:60px;height:3px;margin:.5rem auto 0;background:linear-gradient(90deg,var(--sps-blue),transparent);border-radius:2px}.sps-story-cta p{color:var(--color-text-secondary);max-width:60ch;margin:0 auto}.sps-story-tag{margin-top:1.5rem!important;text-align:center}.sps-story-tag strong{color:var(--sps-blue)}.sps-cta-buttons{display:flex;gap:1rem;justify-content:center;flex-wrap:wrap;margin-top:1.5rem}.sps-cta-btn{display:inline-flex;align-items:center;gap:.5rem;padding:.75rem 1.5rem;font-weight:700;font-size:1rem;border-radius:999px;text-decoration:none;cursor:pointer;border:2px solid #fff0;transition:all 0.25s ease;font-family:inherit}.sps-cta-btn--primary{background:linear-gradient(135deg,var(--sps-blue-dim),var(--sps-blue));color:#fff;border-color:var(--sps-blue)}.sps-cta-btn--primary:hover{background:linear-gradient(135deg,var(--sps-blue),var(--sps-blue-dim));box-shadow:0 0 24px var(--sps-blue-glow);transform:translateY(-2px)}.sps-cta-btn--secondary{background:#fff0;color:var(--sps-blue);border-color:rgb(41 121 255 / .4)}.sps-cta-btn--secondary:hover{background:var(--sps-blue-subtle);border-color:var(--sps-blue)}.sps-feedback{padding:3rem 0}.sps-form{max-width:640px}.sps-form-row{display:grid;grid-template-columns:1fr 1fr;gap:1rem}.sps-form-group{margin-bottom:1.5rem}.sps-label{display:block;font-size:.875rem;font-weight:600;color:var(--color-text-secondary);margin-bottom:.5rem}.sps-optional{color:var(--color-text-muted);font-weight:400}.sps-required{color:#fb7185}.sps-input,.sps-select,.sps-textarea{width:100%;padding:.65rem .85rem;background:var(--glass-bg);border:1px solid rgb(41 121 255 / .25);border-radius:8px;color:var(--color-text-primary);font-size:1rem;line-height:1.4;font-family:inherit;transition:border-color 0.2s ease,box-shadow 0.2s ease;box-sizing:border-box}.sps-input::placeholder,.sps-textarea::placeholder{color:var(--color-text-muted)}.sps-input:focus,.sps-select:focus,.sps-textarea:focus{border-color:var(--sps-blue)!important;box-shadow:0 0 0 3px rgb(41 121 255 / .2)!important;outline:none!important}.sps-select{appearance:none;min-height:2.75rem;background-image:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='16' height='16' fill='%232979ff' viewBox='0 0 16 16'%3E%3Cpath d='M4 6l4 4 4-4'/%3E%3C/svg%3E");background-repeat:no-repeat;background-position:right .75rem center;padding-right:2.5rem}.sps-textarea{resize:vertical;min-height:120px}.sps-form-consent{display:flex;align-items:flex-start;gap:1rem}.sps-checkbox-label{display:flex;align-items:flex-start;gap:1rem;font-size:.875rem;color:var(--color-text-secondary);cursor:pointer}.sps-checkbox{width:18px;height:18px;flex-shrink:0;margin-top:.15rem;accent-color:var(--sps-blue)}.sps-form-error{font-size:.875rem;color:#fca5a5;margin-top:.3rem;min-height:1.2em}.mode-light .sps-form-error{color:#dc2626}.sps-submit-btn{margin-top:1rem}.sps-form-success{margin-top:1.5rem;padding:1rem 1.5rem;background:rgb(41 121 255 / .1);border:1px solid rgb(41 121 255 / .3);border-radius:8px}.sps-form-success p{color:var(--color-text-primary)}.sps-comments{padding:2rem 0}.sps-comments-placeholder{margin-top:1.5rem}.sps-comment-empty{text-align:center;padding:3rem;border:2px dashed rgb(41 121 255 / .25);border-radius:14px;color:var(--color-text-muted)}.sps-comment-empty svg{margin:0 auto 1rem;opacity:.5;stroke:var(--sps-blue)}.sps-comment-empty p{font-style:italic}@media (max-width:640px){.sps-form-row{grid-template-columns:1fr}.sps-cta-buttons{flex-direction:column;align-items:stretch}.sps-cta-btn{justify-content:center}}@media print{.sps-story-cta,.sps-feedback,.sps-comments,.sps-cta-buttons{display:none}}.mode-light .site-content,.mode-light .content-area,.mode-light .page-content,.mode-light main,.mode-light article,.mode-light .post-content{background:transparent!important;background-color:transparent!important}.mode-light .sps-page::before{content:'';position:fixed;inset:0;z-index:-1;pointer-events:none;background:radial-gradient(ellipse 110% 70% at 50% 0%,rgb(184 84 80 / .39),transparent 60%),linear-gradient(180deg,#F7F1E3 0%,#F4EDDC 100%)}.mode-light .sps-page{--color-text-primary:#1F1810;--color-text-secondary:#2B2218;--color-text-muted:#5E4F3D;--color-heading:#1A1208}