:root{--ecd-gold:#F59E0B;--ecd-gold-dim:#D97706;--ecd-gold-glow:rgba(245, 158, 11, 0.25);--ecd-gold-subtle:rgba(245, 158, 11, 0.08);--ecd-warm:#FEF3C7;--ecd-ember:#92400E;--ecd-section-gap:clamp(4rem, 8vw, 7rem);--ecd-glass-bg:rgba(8, 12, 28, 0.58);--ecd-glass-border:rgba(245, 158, 11, 0.16);--ecd-card-shadow:0 4px 24px rgba(0,0,0,0.3), inset 0 1px 0 rgba(255,255,255,0.05);--ecd-glow-gold:0 0 20px rgba(245,158,11,0.20), 0 0 40px rgba(245,158,11,0.08);--ecd-braf-color:#F59E0B;--ecd-mek-color:#FB923C;--ecd-combo-color:#22D3EE;--ecd-erk-color:#10B981;--ecd-focus-ring:0 0 0 3px rgba(245, 158, 11, 0.6);--ecd-focus-ring-offset:0 0 0 1px var(--color-bg-primary, #020617), 0 0 0 4px var(--ecd-gold)}.mode-light{--ecd-glass-bg:rgba(255, 252, 245, 0.88);--ecd-glass-border:rgba(180, 130, 0, 0.18);--ecd-card-shadow:0 4px 16px rgba(0,0,0,0.08), inset 0 1px 0 rgba(255,255,255,0.6);--ecd-glow-gold:0 0 16px rgba(180,130,0,0.12), 0 0 30px rgba(180,130,0,0.06);--ecd-gold-glow:rgba(217, 119, 6, 0.18);--ecd-gold-subtle:rgba(245, 158, 11, 0.06);--ecd-focus-ring-offset:0 0 0 1px var(--color-bg-primary, #F8F8FC), 0 0 0 4px var(--ecd-gold-dim)}.ecd-sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}.ecd-page *:focus-visible{outline:none;box-shadow:var(--ecd-focus-ring-offset);border-radius:var(--radius-xs)}@media (prefers-reduced-motion:reduce){*,*::before,*::after{animation-duration:0.01ms!important;animation-iteration-count:1!important;transition-duration:0.01ms!important;scroll-behavior:auto!important}.ecd-closing-video{display:none}.ecd-hero-intro,.ecd-reality-card,.ecd-pullquote,.ecd-accordion,.ecd-voice-card{animation:none!important}}.ecd-page{width:100%;margin:0 auto;padding:0}.entry-content .ecd-page{max-width:var(--two-col-max-width);margin-inline:auto}.ecd-narrow{max-width:760px;margin-left:auto;margin-right:auto}.ecd-section{padding-top:var(--ecd-section-gap);padding-bottom:var(--ecd-section-gap)}.ecd-section+.ecd-section{border-top:1px solid var(--color-border-subtle,rgb(148 163 184 / .2))}@keyframes ecd-title-gradient{0%{background-position:0% 50%}25%{background-position:50% 50%}50%{background-position:100% 50%}75%{background-position:50% 50%}100%{background-position:0% 50%}}@keyframes ecd-tagline-shimmer{0%{background-position:-200% center}100%{background-position:200% center}}@keyframes ecd-name-shimmer{0%{background-position:-200% center}100%{background-position:200% center}}@keyframes ecd-border-flow{0%,100%{background-position:0% 0%}50%{background-position:0% 100%}}@keyframes ecd-hero-shimmer{0%{left:-120%;opacity:0}10%{opacity:1}100%{left:120%;opacity:0}}@keyframes ecd-ring-pulse{0%{box-shadow:0 0 0 0 rgb(245 158 11 / .45),0 0 12px var(--ecd-gold-glow)}50%{box-shadow:0 0 0 8px #fff0,0 0 20px rgb(245 158 11 / .3)}100%{box-shadow:0 0 0 0 rgb(245 158 11 / .45),0 0 12px var(--ecd-gold-glow)}}@keyframes ecd-pulse{0%,100%{opacity:1;transform:scale(1)}50%{opacity:.4;transform:scale(.7)}}@keyframes ecd-glow-mut{0%{box-shadow:0 0 16px rgb(245 158 11 / .25)}100%{box-shadow:0 0 28px rgb(239 68 68 / .4)}}.ecd-hero-intro{padding:clamp(2.5rem, 5vw, 3.5rem) clamp(1.5rem, 4vw, 3rem);text-align:center;position:relative;overflow:hidden;isolation:isolate;background:var(--ecd-glass-bg);backdrop-filter:blur(12px);-webkit-backdrop-filter:blur(12px);border:1px solid var(--ecd-glass-border);border-radius:var(--radius-xl);box-shadow:var(--ecd-card-shadow);animation:byr-e-rise 0.8s cubic-bezier(.16,1,.3,1) both}.ecd-hero-intro::before{content:'';position:absolute;inset:0;z-index:0;pointer-events:none;background:radial-gradient(ellipse 80% 60% at 50% 110%,rgb(245 158 11 / .14) 0%,transparent 65%),radial-gradient(ellipse 50% 40% at 20% -10%,rgb(34 211 238 / .06) 0%,transparent 60%)}.ecd-hero-intro::after{content:'';position:absolute;inset:0;z-index:2;pointer-events:none;width:60%;height:100%;top:0;background:linear-gradient(110deg,transparent 0%,rgb(255 255 255 / .03) 40%,rgb(255 255 255 / .07) 50%,rgb(255 255 255 / .03) 60%,transparent 100%);animation:ecd-hero-shimmer 1.8s ease-out 1.2s 1 both}.ecd-hero-intro>*{position:relative;z-index:1}.ecd-badge{display:inline-flex;align-items:center;gap:8px;padding:6px 16px;border-radius:var(--radius-pill);background:var(--ecd-gold-subtle);border:1px solid rgb(245 158 11 / .28);font-size:var(--text-sm,.875rem);font-weight:600;color:var(--ecd-gold);letter-spacing:.04em;text-transform:uppercase;margin-bottom:1.5rem}.ecd-badge-dot{width:8px;height:8px;border-radius:50%;background:var(--ecd-gold);animation:ecd-pulse 2.4s ease-in-out infinite}.ecd-hero-title{font-size:clamp(2.25rem, 5vw, 3.5rem);font-weight:900;line-height:var(--leading-tight,1.15);color:var(--color-heading,#FFFFFF);margin:0 0 .75rem;letter-spacing:-.02em}.ecd-hero-title span{background:linear-gradient(125deg,#F59E0B 0%,#FBBF24 18%,#FDE68A 30%,#22D3EE 42%,#FDE68A 54%,#FBBF24 66%,#F59E0B 78%,#D97706 88%,#F59E0B 100%);background-size:300% 300%;-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:#fff0;color:#fff0;animation:ecd-title-gradient 8s ease-in-out infinite;filter:drop-shadow(0 2px 8px rgb(245 158 11 / .35))}@media (forced-colors:active){.ecd-hero-title span,.ecd-accordion-title span,.ecd-reality-card h3,.ecd-author-name,.ecd-closing h2{-webkit-text-fill-color:currentColor;background:none;animation:none;filter:none}}.ecd-hero-cases{font-size:var(--text-lg,1.125rem);color:var(--color-text-secondary,#C7C7D8);margin:0 0 .5rem}.ecd-hero-cases strong{color:var(--ecd-gold);font-weight:700}.ecd-hero-tagline{font-size:var(--text-xl,1.375rem);font-weight:700;font-style:italic;margin:1.5rem 0 0;line-height:var(--leading-snug,1.3);background:linear-gradient(90deg,var(--color-text-primary,#F5F5F8) 0%,rgb(245 158 11 / .85) 40%,var(--color-text-primary,#F5F5F8) 60%,var(--color-text-primary,#F5F5F8) 100%);background-size:200% auto;-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:#fff0;color:#fff0;animation:ecd-tagline-shimmer 5s linear infinite}.ecd-divider{width:120px;height:3px;border:none;border-radius:2px;margin:2.5rem auto;background:linear-gradient(90deg,transparent 0%,var(--ecd-gold) 30%,#FBBF24 50%,var(--ecd-gold) 70%,transparent 100%);opacity:.7}.ecd-welcome p{font-size:var(--text-lg,1.125rem);line-height:var(--leading-relaxed,1.7);color:var(--color-text-primary,#F5F5F8);margin:0 0 1.25rem}.ecd-welcome p:last-child{margin-bottom:0}.ecd-welcome strong{color:var(--ecd-gold);font-weight:700}.ecd-pullquote{position:relative;margin:2.5rem 0;padding:2rem 2rem 2rem 2.75rem;border-radius:0 var(--radius-lg) var(--radius-lg) 0;border-left:none;background:var(--ecd-glass-bg);backdrop-filter:blur(8px);-webkit-backdrop-filter:blur(8px);border:1px solid var(--ecd-glass-border);border-left:none;box-shadow:var(--ecd-card-shadow);animation:byr-e-fade 0.8s ease 0.3s both}.ecd-pullquote::before{content:'';position:absolute;left:0;top:10%;bottom:10%;width:4px;border-radius:2px;background:linear-gradient(180deg,transparent 0%,var(--ecd-gold) 25%,#FBBF24 50%,var(--ecd-gold) 75%,transparent 100%);background-size:100% 200%;animation:ecd-border-flow 3s ease infinite}.ecd-pullquote::after{content:"\201C";position:absolute;top:-12px;left:14px;font-size:6rem;font-weight:900;color:var(--ecd-gold);opacity:.45;line-height:1;pointer-events:none}.ecd-pullquote p{font-size:var(--text-lg,1.125rem);font-style:italic;line-height:var(--leading-relaxed,1.7);color:var(--color-text-primary,#F5F5F8);margin:0}.ecd-author-sig{display:flex;align-items:center;gap:16px;margin-top:2rem;padding:1.25rem 1.5rem;border-radius:var(--radius-lg);background:var(--ecd-glass-bg);backdrop-filter:blur(10px);-webkit-backdrop-filter:blur(10px);border:1px solid var(--ecd-glass-border);box-shadow:var(--ecd-card-shadow)}.ecd-author-avatar{width:52px;height:52px;border-radius:50%;background:linear-gradient(135deg,var(--ecd-gold) 0%,var(--ecd-gold-dim) 100%);box-shadow:0 0 16px rgb(245 158 11 / .35);display:flex;align-items:center;justify-content:center;font-size:var(--text-2xl);font-weight:800;color:#1a1a2e;flex-shrink:0}.ecd-author-info{display:flex;flex-direction:column;gap:2px}.ecd-author-name{font-size:var(--text-md,1rem);font-weight:700;background:linear-gradient(90deg,#FFFFFF 0%,var(--ecd-gold) 40%,#FBBF24 50%,var(--ecd-gold) 60%,#FFFFFF 100%);background-size:200% auto;-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:#fff0;color:#fff0;animation:ecd-name-shimmer 4s ease infinite}.ecd-author-role{font-size:var(--text-sm,.875rem);color:var(--color-text-muted,#8A8A9A)}.ecd-accordion{border:1px solid var(--ecd-glass-border);border-radius:var(--radius-lg);overflow:hidden;margin-bottom:1.25rem;background:var(--ecd-glass-bg);backdrop-filter:blur(8px);-webkit-backdrop-filter:blur(8px);box-shadow:var(--ecd-card-shadow);position:relative;transition:border-color 0.3s ease,box-shadow 0.3s ease}.ecd-accordion::before{content:'';position:absolute;left:0;top:0;bottom:0;width:3px;border-radius:3px 0 0 3px;background:linear-gradient(180deg,transparent 0%,var(--ecd-gold) 25%,#FBBF24 50%,var(--ecd-gold) 75%,transparent 100%);background-size:100% 200%;animation:ecd-border-flow 3s ease infinite;opacity:0;transition:opacity 0.4s ease;z-index:var(--z-content,1)}.ecd-accordion:hover{border-color:rgb(245 158 11 / .3)}.ecd-accordion.is-open{border-color:rgb(245 158 11 / .42);box-shadow:inset 0 0 40px rgb(245 158 11 / .04),var(--ecd-card-shadow)}.ecd-accordion.is-open::before{opacity:1}.ecd-accordion-heading{margin:0;padding:0;font-size:inherit;font-weight:inherit;line-height:inherit}.ecd-accordion-trigger{width:100%;display:flex;align-items:center;justify-content:space-between;gap:16px;padding:clamp(1.25rem, 3vw, 1.75rem) clamp(1.5rem, 3vw, 2rem);background:#fff0;border:none;cursor:pointer;text-align:left;-webkit-appearance:none;appearance:none;font-family:inherit;min-height:60px;transition:background 0.2s ease}.ecd-accordion-trigger:focus-visible{outline:none;box-shadow:inset var(--ecd-focus-ring-offset);border-radius:var(--radius-lg)}.ecd-accordion-trigger:hover{background:var(--ecd-gold-subtle)}.ecd-accordion-trigger-text{display:flex;flex-direction:column;gap:4px;min-width:0}.ecd-accordion-title{font-size:var(--text-2xl);font-weight:900;color:var(--color-heading,#FFFFFF);line-height:var(--leading-tight,1.15);letter-spacing:-.01em}.ecd-accordion-title span{background:linear-gradient(110deg,#F59E0B 0%,#FBBF24 35%,#FB923C 65%,#F59E0B 100%);background-size:200% auto;-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:#fff0;color:#fff0;animation:ecd-title-gradient 6s ease-in-out infinite}.ecd-accordion-subtitle{font-size:var(--text-sm,.875rem);color:var(--color-text-muted,#8A8A9A);line-height:var(--leading-normal,1.5)}.ecd-accordion-icon{width:36px;height:36px;border-radius:50%;background:var(--ecd-gold-subtle);border:1px solid rgb(245 158 11 / .25);display:flex;align-items:center;justify-content:center;flex-shrink:0;transition:transform 0.35s cubic-bezier(.16,1,.3,1),background 0.2s ease,box-shadow 0.2s ease}.ecd-accordion.is-open .ecd-accordion-icon{transform:rotate(180deg);background:rgb(245 158 11 / .18);box-shadow:0 0 12px rgb(245 158 11 / .2)}.ecd-accordion-icon svg{width:18px;height:18px;stroke:var(--ecd-gold);fill:none;stroke-width:2.5;stroke-linecap:round;stroke-linejoin:round}.ecd-accordion-panel{max-height:0;overflow:hidden;transition:max-height 0.45s cubic-bezier(.16,1,.3,1)}.ecd-accordion.is-open .ecd-accordion-panel{max-height:6000px;transition:max-height 0.6s cubic-bezier(.16,1,.3,1)}.ecd-accordion:not(.js-ready) .ecd-accordion-panel{max-height:none}.ecd-accordion-inner{padding:0 clamp(1.5rem, 3vw, 2rem) clamp(1.5rem, 3vw, 2rem);border-top:1px solid rgb(245 158 11 / .12)}.ecd-reality-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:20px;margin-top:2rem}.ecd-reality-card{padding:clamp(1.25rem, 3vw, 1.75rem);border-radius:var(--radius-lg);overflow:hidden;position:relative;background:var(--ecd-glass-bg);backdrop-filter:blur(10px);-webkit-backdrop-filter:blur(10px);border:1px solid var(--ecd-glass-border);box-shadow:var(--ecd-card-shadow);transition:border-color 0.3s ease,transform 0.3s cubic-bezier(.16,1,.3,1),box-shadow 0.3s ease}.ecd-reality-card::before{content:'';position:absolute;top:0;left:20%;right:20%;height:1px;background:linear-gradient(90deg,transparent,rgb(245 158 11 / .45),transparent);pointer-events:none}.ecd-reality-card:hover{border-color:rgb(245 158 11 / .42);transform:translateY(-4px);box-shadow:var(--ecd-glow-gold),var(--ecd-card-shadow)}.ecd-reality-icon{width:56px;height:56px;border-radius:50%;background:rgb(245 158 11 / .1);border:1px solid rgb(245 158 11 / .22);display:flex;align-items:center;justify-content:center;font-size:var(--text-2xl);margin-bottom:1rem;line-height:1;transition:background 0.3s ease,box-shadow 0.3s ease}.ecd-reality-card:hover .ecd-reality-icon{background:rgb(245 158 11 / .16);box-shadow:0 0 16px rgb(245 158 11 / .18)}.ecd-reality-card h3{font-size:var(--text-lg,1.125rem);font-weight:800;margin:0 0 .5rem;line-height:var(--leading-tight,1.15);background:linear-gradient(110deg,var(--ecd-gold) 0%,#FBBF24 55%,#FDE68A 100%);-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:#fff0;color:#fff0}.ecd-reality-card p{font-size:var(--text-md,1rem);color:var(--color-text-secondary,#C7C7D8);line-height:var(--leading-normal,1.5);margin:0}.ecd-pathway-wrap{margin:2rem 0;padding:2rem;border-radius:var(--radius-lg);overflow-x:auto;-webkit-overflow-scrolling:touch;background:var(--ecd-glass-bg);backdrop-filter:blur(8px);-webkit-backdrop-filter:blur(8px);border:1px solid var(--ecd-glass-border);box-shadow:var(--ecd-card-shadow)}.ecd-pathway-wrap:focus-visible{box-shadow:var(--ecd-focus-ring-offset)}.ecd-pathway-label{font-size:var(--text-sm,.875rem);font-weight:700;text-transform:uppercase;letter-spacing:.06em;color:var(--color-text-muted,#8A8A9A);margin:0 0 1.5rem}.ecd-pathway-chain{display:flex;align-items:center;gap:0;flex-wrap:nowrap;min-width:max-content;padding-bottom:.5rem}.ecd-pathway-node{display:flex;flex-direction:column;align-items:center;gap:6px;min-width:90px;flex-shrink:0}.ecd-pathway-node-circle{width:56px;height:56px;border-radius:50%;display:flex;align-items:center;justify-content:center;font-size:var(--text-sm);font-weight:800;letter-spacing:.02em;color:#0F172A;position:relative}.ecd-pathway-node-circle.normal{background:linear-gradient(135deg,#22D3EE,#3B82F6);box-shadow:0 0 16px rgb(34 211 238 / .25)}.ecd-pathway-node-circle.mutated{background:linear-gradient(135deg,var(--ecd-gold),#EF4444);box-shadow:0 0 20px rgb(245 158 11 / .35);animation:ecd-glow-mut 2s ease-in-out infinite alternate}.ecd-pathway-node-circle.target{background:linear-gradient(135deg,#10B981,#059669);box-shadow:0 0 16px rgb(16 185 129 / .3)}.ecd-pathway-node-name{font-size:var(--text-xs);font-weight:700;color:var(--color-text-primary,#F5F5F8);text-align:center;line-height:1.2}.ecd-pathway-node-note{font-size:var(--text-xs);color:var(--color-text-muted,#8A8A9A);text-align:center;max-width:100px;line-height:1.2}.ecd-pathway-arrow{display:flex;align-items:center;justify-content:center;width:40px;flex-shrink:0;position:relative}.ecd-pathway-arrow::before{content:"";width:100%;height:2px;background:var(--color-border-subtle,rgb(148 163 184 / .35))}.ecd-pathway-arrow::after{content:"\203A";position:absolute;right:-2px;font-size:var(--text-xl);color:var(--color-text-muted,#8A8A9A)}.ecd-pathway-bolt{position:absolute;top:-6px;right:-6px;font-size:var(--text-md);filter:drop-shadow(0 0 4px rgb(245 158 11 / .6))}.ecd-pathway-legend{display:flex;flex-wrap:wrap;gap:1.25rem;margin-top:1.5rem;padding-top:1rem;border-top:1px solid rgb(245 158 11 / .12)}.ecd-legend-item{display:flex;align-items:center;gap:8px;font-size:var(--text-sm,.875rem);color:var(--color-text-secondary,#C7C7D8)}.ecd-legend-dot{width:12px;height:12px;border-radius:50%;flex-shrink:0}.ecd-legend-dot.normal{background:linear-gradient(135deg,#22D3EE,#3B82F6)}.ecd-legend-dot.mutated{background:linear-gradient(135deg,var(--ecd-gold),#EF4444)}.ecd-legend-dot.target{background:linear-gradient(135deg,#10B981,#059669)}.ecd-mutation-stats{display:flex;flex-direction:column;gap:1.25rem;margin:2rem 0 0}.ecd-stat-row{display:flex;flex-direction:column;gap:6px}.ecd-stat-label{display:flex;justify-content:space-between;align-items:baseline;font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8)}.ecd-stat-label strong{font-weight:700}.ecd-stat-pct{font-weight:800;color:var(--ecd-gold)}.ecd-stat-bar-track{width:100%;height:8px;border-radius:var(--radius-xs);background:rgb(148 163 184 / .12);overflow:hidden}.ecd-stat-bar-fill{height:100%;border-radius:var(--radius-xs);transition:width 1.5s cubic-bezier(.16,1,.3,1)}.ecd-stat-bar-fill.gold{background:linear-gradient(90deg,var(--ecd-gold),#FBBF24)}.ecd-stat-bar-fill.amber{background:linear-gradient(90deg,var(--ecd-gold-dim),var(--ecd-gold))}.ecd-stat-bar-fill.slate{background:linear-gradient(90deg,#64748B,#94A3B8)}.ecd-stat-note{font-size:var(--text-sm,.875rem);color:var(--color-text-muted,#8A8A9A);line-height:var(--leading-normal,1.5);margin-top:.25rem}.ecd-treatment-tracks{display:grid;grid-template-columns:1fr 1fr;gap:20px;margin-top:1.5rem}.ecd-treatment-card{padding:clamp(1.25rem, 3vw, 1.75rem);padding-top:calc(clamp(1.25rem, 3vw, 1.75rem) + 4px);border-radius:var(--radius-lg);overflow:hidden;position:relative;background:var(--ecd-glass-bg);backdrop-filter:blur(10px);-webkit-backdrop-filter:blur(10px);border:1px solid var(--ecd-glass-border);box-shadow:var(--ecd-card-shadow);transition:border-color 0.3s ease,transform 0.3s cubic-bezier(.16,1,.3,1),box-shadow 0.3s ease}.ecd-treatment-card::before{content:'';position:absolute;top:0;left:0;right:0;height:3px;border-radius:var(--radius-lg) var(--radius-lg) 0 0}.ecd-treatment-tracks .ecd-treatment-card:nth-child(1)::before{background:linear-gradient(90deg,var(--ecd-braf-color),#FBBF24);box-shadow:0 0 12px rgb(245 158 11 / .45)}.ecd-treatment-tracks .ecd-treatment-card:nth-child(2)::before{background:linear-gradient(90deg,var(--ecd-mek-color),#FCA5A5);box-shadow:0 0 12px rgb(251 146 60 / .45)}.ecd-treatment-tracks .ecd-treatment-card:nth-child(3)::before{background:linear-gradient(90deg,var(--ecd-combo-color),#38BDF8);box-shadow:0 0 12px rgb(34 211 238 / .45)}.ecd-treatment-tracks .ecd-treatment-card:nth-child(4)::before{background:linear-gradient(90deg,var(--ecd-erk-color),#34D399);box-shadow:0 0 12px rgb(16 185 129 / .45)}.ecd-treatment-tracks .ecd-treatment-card h3{display:flex;align-items:center;gap:.5rem}.ecd-treatment-tracks .ecd-treatment-card h3 .byr-icon{font-size:1.1em;flex-shrink:0}.ecd-treatment-card:hover{border-color:rgb(245 158 11 / .42);transform:translateY(-3px);box-shadow:var(--ecd-glow-gold),var(--ecd-card-shadow)}.ecd-treatment-card h3{font-size:var(--text-lg,1.125rem);font-weight:800;color:var(--color-heading,#FFFFFF);margin:0 0 .25rem;line-height:var(--leading-tight,1.15)}.ecd-treatment-for{font-size:var(--text-sm,.875rem);color:var(--ecd-gold);font-weight:600;margin:0 0 .75rem}.ecd-treatment-card p{font-size:var(--text-md,1rem);color:var(--color-text-secondary,#C7C7D8);line-height:var(--leading-normal,1.5);margin:0}.ecd-drug-list{font-size:var(--text-md,1rem);color:var(--color-text-primary,#F5F5F8);font-weight:600;margin:.5rem 0 0}.ecd-treatment-note{grid-column:1 / -1;padding:1.5rem 2rem;border-radius:var(--radius-lg);background:var(--ecd-glass-bg);backdrop-filter:blur(8px);-webkit-backdrop-filter:blur(8px);border:1px solid rgb(245 158 11 / .2);box-shadow:var(--ecd-card-shadow)}.ecd-treatment-note p{font-size:var(--text-md,1rem);line-height:var(--leading-relaxed,1.7);color:var(--color-text-primary,#F5F5F8);margin:0}.ecd-treatment-note strong{color:var(--ecd-gold);font-weight:700}.ecd-trials-grid{display:grid;grid-template-columns:1fr 1fr;gap:20px;margin-top:1.5rem}.ecd-trial-card{padding:1.5rem;border-radius:var(--radius-lg);display:flex;flex-direction:column;gap:8px;background:var(--ecd-glass-bg);backdrop-filter:blur(10px);-webkit-backdrop-filter:blur(10px);border:1px solid 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var(--ecd-gold-glow);transform:translateY(-2px)}.ecd-cta-btn--secondary{background:#fff0;color:var(--ecd-gold);border-color:rgb(245 158 11 / .4)}.ecd-cta-btn--secondary:hover{background:var(--ecd-gold-subtle);border-color:var(--ecd-gold)}.ecd-feedback{padding:3rem 0}.ecd-form{max-width:640px}.ecd-form-row{display:grid;grid-template-columns:1fr 1fr;gap:1rem}.ecd-form-group{margin-bottom:1.5rem}.ecd-label{display:block;font-size:.875rem;font-weight:600;color:var(--color-text-secondary);margin-bottom:.5rem}.ecd-optional{color:var(--color-text-muted);font-weight:400}.ecd-required{color:#fb7185}.ecd-input,.ecd-select,.ecd-textarea{width:100%;padding:.65rem .85rem;background:var(--glass-bg);border:1px solid rgb(245 158 11 / .25);border-radius:8px;color:var(--color-text-primary);font-size:1rem;line-height:1.4;font-family:inherit;transition:border-color 0.2s ease,box-shadow 0.2s ease;box-sizing:border-box}.ecd-input::placeholder,.ecd-textarea::placeholder{color:var(--color-text-muted)}.ecd-input:focus,.ecd-select:focus,.ecd-textarea:focus{border-color:var(--ecd-gold)!important;box-shadow:0 0 0 3px rgb(245 158 11 / .2)!important;outline:none!important}.ecd-select{appearance:none;min-height:2.75rem;background-image:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='16' height='16' fill='%23f59e0b' viewBox='0 0 16 16'%3E%3Cpath d='M4 6l4 4 4-4'/%3E%3C/svg%3E");background-repeat:no-repeat;background-position:right .75rem center;padding-right:2.5rem}.ecd-textarea{resize:vertical;min-height:120px}.ecd-form-consent{display:flex;align-items:flex-start;gap:1rem}.ecd-checkbox-label{display:flex;align-items:flex-start;gap:1rem;font-size:.875rem;color:var(--color-text-secondary);cursor:pointer}.ecd-checkbox{width:18px;height:18px;flex-shrink:0;margin-top:.15rem;accent-color:var(--ecd-gold)}.ecd-form-error{font-size:.875rem;color:#fca5a5;margin-top:.3rem;min-height:1.2em}.mode-light .ecd-form-error{color:#dc2626}.ecd-submit-btn{margin-top:1rem}.ecd-form-success{margin-top:1.5rem;padding:1rem 1.5rem;background:rgb(245 158 11 / .1);border:1px solid rgb(245 158 11 / .3);border-radius:8px}.ecd-form-success p{color:var(--color-text-primary)}.ecd-comments{padding:2rem 0}.ecd-comments-placeholder{margin-top:1.5rem}.ecd-comment-empty{text-align:center;padding:3rem;border:2px dashed rgb(245 158 11 / .25);border-radius:14px;color:var(--color-text-muted)}.ecd-comment-empty svg{margin:0 auto 1rem;opacity:.5;stroke:var(--ecd-gold)}.ecd-comment-empty p{font-style:italic}@media (max-width:640px){.ecd-form-row{grid-template-columns:1fr}.ecd-cta-buttons{flex-direction:column;align-items:stretch}.ecd-cta-btn{justify-content:center}}@media print{.ecd-story-cta,.ecd-feedback,.ecd-comments,.ecd-cta-buttons{display:none}}